ABDOMINAL
ABDOMINAL STATION
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Alveolar tipe I
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Alveolar type II
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Alveolar type III
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None of the above
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Detailed explanation-1: -We propose the hypothesis that the main target of the virus is the Alveolar Epithelial Cell Type II and that a dysregulation of the Nuclear Factor kappa-light-chain-enhancer of activated B cells pathway (NF-B pathway) drives ARDS leading to Multiple Organ Failure (MOF), one of the most frequent causes of death.
Detailed explanation-2: -The virus now reaches the gas exchange units of the lung and infects alveolar type II cells. Both SARS-CoV and influenza preferentially infect type II cells compared to type I cells [11, 12]. The infected alveolar units tend to be peripheral and subpleural [13, 14].
Detailed explanation-3: -In the early stage of SARS-CoV-2 infection, the virus replicates rapidly but actively avoids attracting “first responder” immune cells-called “neutrophils”-which can initiate early inflammation and clearance of the virus.
Detailed explanation-4: -Type II cells are defenders of the alveoli by secreting surfactant, keeping the alveolar space relatively free from fluid, serving as progenitor cells to repopulate the epithelium after injury, and providing important components of the innate immune system.