MRCP UK EXAMINATIONS

Detailed explanation-1: -Primary biliary cirrhosis (PBC) is an autoimmune liver disease with an incompletely understood etiology characterized by portal inflammation and immune-mediated destruction of the intrahepatic bile ducts leading to cholestasis and occasionally to fibrosis and secondary biliary cirrhosis (1).

Detailed explanation-2: -PBC, formerly known as primary biliary cirrhosis, is a chronic inflammatory autoimmune cholestatic liver disease characterized by the destruction of small intrahepatic bile ducts, leading to fibrosis and eventually cirrhosis and its complications 9, 10.

Detailed explanation-3: -Untreated autoimmune hepatitis can lead to scarring of the liver (cirrhosis) and eventually to liver failure. When diagnosed and treated early, however, autoimmune hepatitis often can be controlled with drugs that suppress the immune system.

Detailed explanation-4: -Celiac disease. Raynaud phenomenon. Sicca syndrome (dry eyes or mouth) Thyroid disease.