MRCP UK EXAMINATIONS

ABDOMINAL

CHRONIC LIVER DISEASE

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
Select what characterizes cirrhosis of the liver.
A
Widespread fibrotic (scarred) bands of connective tissue
B
Tissue becomes nodular
C
Nodules block blood and lymph flow
D
Liver shrinks in size and softens
E
Reversible if treated in early stages hardens Cirrhosis is a late stage of scarring (fibrosis) of the liver caused by many forms of liver diseases and conditions, such as hepatitis and chronic alcoholism. Each time your liver is injured-whether by disease, excessive alcohol consumption or another cause-it tries to repair itself. In the process, scar tissue forms. As cirrhosis progresses, more and more scar tissue forms, making it difficult for the liver to function (decompensated cirrhosis). Advanced cirrhosis is life-threatening.
Explanation: 

Detailed explanation-1: -Cirrhotic liver nodules were classified into regenerative, dysplastic, and neoplastic nodules [3]. Dysplastic or neoplastic nodules are composed of hepatocytes with atypia caused by genetic alteration.

Detailed explanation-2: -Liver cirrhosis is characterized by irreversible remodeling of the hepatic architecture with bridging fibrosis and a spectrum of hepatocellular nodules (, 1). Cirrhosis-associated hepatocellular nodules result from the localized proliferation of hepatocytes and their supporting stroma in response to liver injury (, 2).

There is 1 question to complete.