MRCP UK EXAMINATIONS

Detailed explanation-1: -Clinically, cholestasis leads to retention of the constituents of bile in blood. The 2 major constituents of bile are bilirubin and bile acids. Thus biochemically, cholestasis is marked by the elevation of predominantly serum alkaline phosphatase.

Detailed explanation-2: -Bile passes out of the liver through the bile ducts and is stored in the gallbladder. After a meal, it is released into the small intestine. When the bile ducts become blocked, bile builds up in the liver, and jaundice (yellow color of the skin) develops due to the increasing level of bilirubin in the blood.

Detailed explanation-3: -GGT levels can be elevated in the following: Biliary duct obstruction e.g. gallstonesInfection of the gallbladder-cholecystitis (this typically occurs following an obstruction within the biliary system) In acute or chronic liver disease (which may be caused by hepatitis)

Detailed explanation-4: -Your doctor can diagnose ICP from blood tests called liver blood tests and a serum bile salt test. Liver blood tests are performed to gain an idea of how your liver is functioning. A number of separate properties of your blood will be examined.