MRCP UK EXAMINATIONS

Detailed explanation-1: -The enzyme involved in this reaction is an aminotransferase. The -ketoglutarate family of amino acid synthesis (synthesis of glutamate, glutamine, proline and arginine) begins with -ketoglutarate, an intermediate in the Citric Acid Cycle.

Detailed explanation-2: -Ornithine is an intermediate of the urea cycle and, thus, a central metabolite of arginine synthesis and degradation [7] (Fig 1). Arginine synthesis from ornithine takes place in chloroplasts [8]. In a first step, ornithine is carbamoylated to citrulline.