MRCP UK EXAMINATIONS

ABDOMINAL

CHRONIC LIVER DISEASE

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
What type of reaction is the addition of ammonia to an intermediate?
A
dehydration
B
reduction
C
condensation
D
hydrolysis
Explanation: 

Detailed explanation-1: -The Mannich reaction is a condensation reaction.

Detailed explanation-2: -One of the most important examples of a nucleophilic addition reaction in biochemistry, and in carbohydrate chemistry in particular, is the addition of an alcohol to a ketone or aldehyde.

Detailed explanation-3: -The Mannich reaction is an organic reaction which consists of an amino alkylation of an acidic proton placed next to a carbonyl functional group by formaldehyde and a primary or secondary amine or ammonia. The final product is a -amino-carbonyl compound also known as a Mannich base.

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