MRCP UK EXAMINATIONS

ABDOMINAL

CHRONIC LIVER DISEASE

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
when are increased blood levels present? (ALP)
A
when cholestasis or bone degeneration is present
B
when myleostasis or enzyme synthesis is present
C
when lipostasis or bone synthesis is present
D
when cholestasis or protein degeneration is present
Explanation: 

Detailed explanation-1: -ALP rises because of the increased synthesis and membrane shedding of ALP from hepatocytes exposed to the increased biliary pressure of cholestasis whereas bilirubin rises due to a failure of bilirubin excretion.

Detailed explanation-2: -People with Paget’s disease of bone often have raised levels of ALP, although some people with the condition have a normal ALP level and a high level can also be caused by some other conditions. An X-ray or scan is therefore also needed to confirm the diagnosis.

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