MRCP UK EXAMINATIONS

Detailed explanation-1: -The gastric chief cells are epithelial cells in the gastric glands in the stomach lining. They are responsible for the secretion of pepsinogen and gastric lipase. In humans, the gastric chief cells are stimulated by the acidic condition of the stomach as well as through the cholinergic activity from the vagus nerve.

Detailed explanation-2: -Immunochemical studies revealed that human gastric lipase (HGL) is secreted by the chief (zymogen) cells of gastric mucosa [4]. HGL takes part in digestion of fats, and it accounts for approximately 40% of preduodenal lipolysis.

Detailed explanation-3: -Structure. The chief cells secrete pepsinogen, a moderately sized zymogen protein with a molecular weight of 40, 400. Pepsin, an enzyme with a molecular weight of 32, 700, is formed in the acidic environment of the stomach when pepsinogen loses its activation peptides.

Detailed explanation-4: -The chief cells secrete the zymogen pepsinogen and the enzyme gastric lipase.

Detailed explanation-5: -The gastric chief cell (also known as a zymogenic cell or peptic cell) is a cell in the stomach that releases pepsinogen and chymosin. Pepsinogen is activated into the digestive enzyme pepsin when it comes in contact with hydrochloric acid produced by gastric parietal cells.