MRCP UK EXAMINATIONS

Detailed explanation-1: -In general, lipid-soluble drugs, and drugs composed of smaller molecules, cross the cell membrane more easily and are more likely to be absorbed by passive diffusion.

Detailed explanation-2: -Regardless of the route of administration, drugs must be in solution to be absorbed. Thus, solid forms (eg, tablets) must be able to disintegrate and deaggregate. Sometimes various globular proteins embedded in the matrix function as receptors and help transport molecules across the membrane.

Detailed explanation-3: -For these reasons, most drugs are absorbed primarily in the small intestine, and acids, despite their ability as un-ionized drugs to readily cross membranes, are absorbed faster in the intestine than in the stomach (for review, see [ 1.

Detailed explanation-4: -After a drug is administered, it is absorbed into the bloodstream. The circulatory system then distributes the drug throughout the body. Then it is metabolized by the body. The drug and its metabolites are then excreted.