MRCP UK EXAMINATIONS

Detailed explanation-1: -It does not appear that gastrin has a significant effect on gastric emptying rate, but the induction of acid secretion and increase in intragastric volume may result in a slight prolongation of emptying of all gastric content.

Detailed explanation-2: -Gastrin is a peptide hormone primarily responsible for enhancing gastric mucosal growth, gastric motility, and secretion of hydrochloric acid (HCl) into the stomach. It is present in G cells of the gastric antrum and duodenum.

Detailed explanation-3: -Among the various peptides, so far investigated, gastrin inhibits the emptying rate, however, this effect is only seen at unphysiological high concentrations. Cholecystokinin, on the other hand, is able to decrease the delivery of glucose to the duodenum at physiological concentrations.

Detailed explanation-4: -Stomach motility and gastric emptying Gastric emptying is also inhibited when nutrients enter the small intestine. This regulation-called feedback control-already happens in the duodenum where it is called the “duodenal brake.” Calorific food slows gastric emptying more than non-calorific gum cellulose.