MRCP UK EXAMINATIONS

ABDOMINAL

GASTROINTESTINAL

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
HCL acid from gastric juice is produced in cells
A
D cells
B
main
C
none
D
parietal
Explanation: 

Detailed explanation-1: -Hydrochloric acid secreted from gastric parietal cells generates the strongly acidic environment of the gastric lumen (pH <2) (305), which kills food-derived bacteria, facilitates food digestion, and promotes absorption of minerals including phosphate, calcium, and iron.

Detailed explanation-2: -The tight regulation of parietal cells ensures the proper secretion of HCl. The H+-K+-ATPase enzyme expressed in parietal cells regulates the exchange of cytoplasmic H+ for extracellular K+. The H+ secreted into the gastric lumen by the H+-K+-ATPase combines with luminal Cl-to form gastric acid, HCl.

Detailed explanation-3: -Parietal cells (also known as oxyntic cells) are epithelial cells in the stomach that secrete hydrochloric acid (HCl) and intrinsic factor. These cells are located in the gastric glands found in the lining of the fundus and body regions of the stomach.

Detailed explanation-4: -When stimulated, parietal cells secrete HCl at a concentration of roughly 160 mM (equivalent to a pH of 0.8). The acid is secreted into large cannaliculi, deep invaginations of the plasma membrane which are continuous with the lumen of the stomach.

Detailed explanation-5: -HCl is produced by the parietal cells of the stomach.

There is 1 question to complete.