MRCP UK EXAMINATIONS

Detailed explanation-1: -Hydrochloric acid secreted from gastric parietal cells generates the strongly acidic environment of the gastric lumen (pH <2) (305), which kills food-derived bacteria, facilitates food digestion, and promotes absorption of minerals including phosphate, calcium, and iron.

Detailed explanation-2: -When stimulated, parietal cells secrete HCl at a concentration of roughly 160 mM (equivalent to a pH of 0.8). The acid is secreted into large cannaliculi, deep invaginations of the plasma membrane which are continuous with the lumen of the stomach.

Detailed explanation-3: -Parietal cells (also known as oxyntic cells) are epithelial cells in the stomach that secrete hydrochloric acid (HCl) and intrinsic factor. These cells are located in the gastric glands found in the lining of the fundus and body regions of the stomach.

Detailed explanation-4: -Final answer: HCl Is secreted by Parietal Cell of the stomach.

Detailed explanation-5: -Histamine stimulates the parietal cells to secrete HCl. The gastrin-ECL cell pathway has been investigated extensively in situ (gastric submucosal microdialysis), in vitro (isolated ECL cells) and in vivo (intact animals).