ABDOMINAL
GASTROINTESTINAL
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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It reaches its highest activity at a pH of 5.
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Pepsin has the ability to digest collagen
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Contributes with 30-40% of protein digestion
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Deactivates with a pH between 2-3
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Detailed explanation-1: -During pepsin digestion, pepsin cleaves collagen at the telopeptide region causing the protein to unfold (Figure 1B).
Detailed explanation-2: -In particular, pepsin digestion could lead to a decrease in denaturation temperature due to decreased molecular weight of collagen subunits by the removal of telopeptides region (Nalinanon et al., 2007).
Detailed explanation-3: -COLLAGEN CLEAVAGE. Collagenase is the only proteinase that can cleave the triple helix of type II collagen in cartilage and type I and III collagens in other tissues.
Detailed explanation-4: -It breaks down proteins into smaller peptides and amino acids that can be easily absorbed in the small intestine. Specific cells within the gastric lining, known as chief cells, release pepsin in an inactive form, or zymogen form, called pepsinogen.