MRCP UK EXAMINATIONS

Detailed explanation-1: -Motilin is the hormone that is cyclically released during the fasted state and is released by the entero-endocrine cells (Mo cells) in the upper small intestine.

Detailed explanation-2: -GI motility is controlled by contractility of smooth muscles of the GI tract, extrinsic and intrinsic neurons (motor and sensory) and some hormones. In mammals, ghrelin (GHRL) and motilin (MLN) stimulate appetite and GI motility and contribute to the regulation of energy homeostasis.

Detailed explanation-3: -Why is motilin secreted during fasting? The migrating motor complex or MMC is timed to help your body move food through your digestive tract. Motilin is part of the MMC. As you eat, stomach enzymes are secreted to start the process of breaking down food.

Detailed explanation-4: -The main function of motilin is to increase the migrating myoelectric complex component of gastrointestinal motility and stimulate the production of pepsin. Motilin is also called “housekeeper of the gut” because it improves peristalsis in the small intestine and clears out the gut to prepare for the next meal.