MRCP UK EXAMINATIONS

Detailed explanation-1: -Myenteric interstitial cells of Cajal (ICC-MY) serve as pacemaker cells that generate the bioelectrical events known as slow waves. Slow waves conduct to smooth muscle cells and cause phasic contractions.

Detailed explanation-2: -Interstitial cells of Cajal (ICC) are pacemaker cells that generate electrical slow waves in gastrointestinal (GI) smooth muscles. Slow waves organize basic motor patterns, such as peristalsis and segmentation in the GI tract. Slow waves depend upon activation of Ca2+-activated Cl– channels (CaCC) encoded by Ano1.

Detailed explanation-3: -Interstitial cells of Cajal of the deep muscular plexus (ICC-DMP) are the cell types found in the deep muscular plexus. These multipolar cells are associated closely with the nerve bundles of the deep muscular plexus.

Detailed explanation-4: -Specialized cells known as interstitial cells of Cajal (ICC) are distributed in specific locations within the tunica muscularis of the gastrointestinal tract and serve as electrical pacemakers, active propagation pathways for slow waves, and mediators of enteric motor neurotransmission.

Detailed explanation-5: -Interstitial cells of Cajal generate electrical slow waves in the murine stomach-PMC.