MRCP UK EXAMINATIONS

Detailed explanation-1: -Gastric chief cells secrete pepsin as an inactive zymogen called pepsinogen. Parietal cells within the stomach lining secrete hydrochloric acid that lowers the pH of the stomach.

Detailed explanation-2: -Pepsinogen is secreted from peptic (or chief) cells in the oxyntic gland. Some pepsinogen is also secreted from mucosal cells in the gastric antrum and the duodenum. In the presence of gastric acid this proenzyme is converted into active pepsin, which itself catalyzes further conversion from pepsinogen.

Detailed explanation-3: -Gastric chief cell (also known as a zymogenic cell or peptic cell) is a cell in the stomach, that releases pepsinogen and chymosin. Pepsinogen is activated into the digestive enzyme pepsin, when it comes in contact with acid produced by gastric parietal cells.

Detailed explanation-4: -The gastric chief cell (also known as a zymogenic cell or peptic cell) is a cell in the stomach that releases pepsinogen and chymosin. Pepsinogen is activated into the digestive enzyme pepsin when it comes in contact with hydrochloric acid produced by gastric parietal cells.

Detailed explanation-5: -Structure. The chief cells secrete pepsinogen, a moderately sized zymogen protein with a molecular weight of 40, 400. Pepsin, an enzyme with a molecular weight of 32, 700, is formed in the acidic environment of the stomach when pepsinogen loses its activation peptides.