MRCP UK EXAMINATIONS

Detailed explanation-1: -The migrating motor complex (MMC) is the ENS-programmed small intestinal motility pattern of the interdigestive state. It starts when digestion and absorption is complete and the intestine is empty of nutrients 2–3 h after a meal.

Detailed explanation-2: -The duodenum, which stores motilin, plays an important role to initiate gastric MMC in dogs and humans. Motilin-immunoreactive cells are most frequent in the duodenal and jejunal mucosa and are concentrated in the deeper portion of the crypt of the human and dog intestine.

Detailed explanation-3: -For example, the MMC is thought to be initiated by motilin, and it does not directly depend on extrinsic nerves. Additionally, gastrin, insulin, cholecystokinin, glucagon, and secretin have been reported to disrupt the MMC.

Detailed explanation-4: -Motilin and ghrelin are the gastrointestinal (GI) hormones released in a fasting state to stimulate the GI motility of the migrating motor complex (MMC).

Detailed explanation-5: -The periodic nature of the migrating motor complex is thought to be controlled from the central nervous system and may be implemented in part by the enteric hormone motilin.