MRCP UK EXAMINATIONS

Detailed explanation-1: -Enterokinase (also known as enteropeptidase) is an enzyme secreted from the brush border of the small intestine, also in response to secretin and CCK.

Detailed explanation-2: -Enteropeptidase (enterokinase [E.C. 3.4. 21.9]) is a serine protease of the intestinal brush border in the proximal small intestine.

Detailed explanation-3: -structure and function in human digestive system In lactase. It is a so-called brush border enzyme, produced by cells known as enterocytes that line the intestinal walls and form the brush border (a chemical barrier through which food must pass to be absorbed).

Detailed explanation-4: -Enzyme structure Enteropeptidase is a type II transmembrane serine protease (TTSP) localized to the brush border of the duodenal and jejunal mucosa and synthesized as a zymogen, proenteropeptidase, which requires activation by duodenase or trypsin.

Detailed explanation-5: -Enteropeptidase converts trypsinogen into active trypsin, which not only hydrolyses some peptide bonds of food proteins but also activates a number of pancreatic zymogens. For this reason enteropeptidase is a key enzyme in the digestion of dietary proteins and its absence may result in gross protein malabsorption.