MRCP UK EXAMINATIONS

Detailed explanation-1: -Phospholipids. The predominant PL in the lumen of the small intestine is PC, which is found in mixed micelles that also contain cholesterol and bile salts. The digestion of PLs is carried out primarily by pancreatic phospholipase A2 (pPLA2) and other lipases secreted by the pancreas in response to food intake.

Detailed explanation-2: -6. Lipolytic digestion by pancreatic enzymes in the lumen of the small intestine. Pancreatic lipase, anchored and activated by pancreatic colipase, breaks triglycerides down into fatty acids and monoglycerides. Pancreatic phospholipase cleaves phospholipids into fatty acids and lysophospholipids.

Detailed explanation-3: -Colipase, abbreviated CLPS, is a protein co-enzyme required for optimal enzyme activity of pancreatic lipase. It is secreted by the pancreas in an inactive form, procolipase, which is activated in the intestinal lumen by trypsin.

Detailed explanation-4: -Colipase is a protein that functions as a cofactor for pancreatic lipase, with which it forms a stoichiometric complex. It also binds to the bile-salt covered triacylglycerol interface thus allowing the enzyme to anchor itself to the water-lipid interface.