ABDOMINAL
GASTROINTESTINAL
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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In the duodenal mucosa in response to the arrival of gastric acid
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In the esophageal mucosa in response to the arrival of a food bolus
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In the gastric mucosa in response to the arrival of the bolus and the mixture
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None of the above
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Detailed explanation-1: -Secretin is also secreted by specific endocrine cells in the mucosa of the proximal small intestine and expressed in smaller numbers in the jejunum of duodenum (2, 29).
Detailed explanation-2: -Secretin is secreted by S cells in the duodenum and affects numerous other organ systems. Secretin receptors (SR) are expressed in the basolateral domain of several cell types. [3] Besides regulating the growth of epithelial cells in the pancreas and biliary system, secretin additionally exerts trophic effects.
Detailed explanation-3: -Secretin is secreted in response to one known stimulus: acidification of the duodenum, which occurs most commonly when liquified ingesta from the stomach are released into the small intestine.
Detailed explanation-4: -Regulation of synthesis and release Secretin is synthesized and secreted by S cells in the small intestine, and neurons in the brain. Secretin release is mainly stimulated by gastric acid delivered into the duodenal lumen.
Detailed explanation-5: -Secretin is secreted from S cells in the duodenum in response to H+ and fatty acids in the lumen. Specifically, a pH less than 4.5 signals arrival of gastric contents, which initiates the release of secretin.