MRCP UK EXAMINATIONS

ABDOMINAL

GASTROINTESTINAL

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
Which of the following is a feedback pathway of the gastrointestinal system?
A
Arrival of chyme in the intestine
B
CCK secretion
C
Motility inhibition
D
Decreased insulin secretion
Explanation: 

Detailed explanation-1: -CCK is produced by two separate cell types: endocrine cells of the small intestine and various neurons in the gastrointestinal tract and central nervous system.

Detailed explanation-2: -Cholecystokinin (CCK) is a hormone secreted by the I-cells of the upper small intestine in response to fat, protein, and some nonnutrients, for example, camostat, and a peptide/neurotransmitter secreted by neurons of the central and peripheral nervous systems.

Detailed explanation-3: -CCK receptors signal through the phosphatidyl inositol pathway. This leads to increases in diacylglycerol and intracellular Ca2+. Also, CCK has been shown to increase levels of cyclic guanosine monophosphate (cGMP).

Detailed explanation-4: -In addition to the role of neural pathways, the hormone CCK plays a major role in meal-stimulated digestive enzyme secretion during the intestinal phase.

There is 1 question to complete.