MRCP UK EXAMINATIONS

Detailed explanation-1: -Somatostatin is known to inhibit gastric acid secretion via both inhibition of histamine release from gastric enterochromaffin-like cells and direct inhibition of parietal cell function.

Detailed explanation-2: -Gastric delta cells (D-cells), which are somatostatin-secreting cells, are the main paracrine inhibitor of acid secretion.

Detailed explanation-3: -Somatostatin thus lowers gastrin secretion and hydrochloric acid production, while in the small intestines it lowers the secretion of a number of other gastrointestinal hormones, thus inhibiting transit time and bile acid production.