MRCP UK EXAMINATIONS

ABDOMINAL

GENERALISED LYMPHADENOPATHY

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
A 42-year-old patient complained of a voice timbre change. The larynx biopsy was taken. A histological investigation revealed the aggregates of large, oblong form cells with light nuclei, rich with a cytoplasm. The nuclei were located on periphery in the form of a horseshoe. The described histological changes are characteristic for:
A
Tuberculosis
B
Leprosy
C
Syphilis
D
Rhinoscleroma
Explanation: 

Detailed explanation-1: -EPTB refers to TB involving organs other than the lungs (e.g., pleura, lymph nodes, abdomen, genitourinary tract, skin, joints and bones, or meninges). A patient with both pulmonary and EPTB is classified as a case of PTB. For example, miliary TB is classified as PTB because there are lesions in the lungs.

Detailed explanation-2: -The diagnosis of tuberculous lymphadenitis may require a biopsy. Other possible diagnostic steps include: positive tuberculin test, chest radiograph, CT scan, cytology/biopsy (FNAC), AFB staining, and mycobacterial culture.

Detailed explanation-3: -As cell death begins, the granuloma forms and cell death continues the inflammatory response is mediated by a type IV hypersensitivity reaction.

Detailed explanation-4: -General signs (weight loss, sweats, fever, and asthenia) are found in 20 to 50% [6, 7]. The lymph node TB usually causes a painful swelling of one or more lymph nodes. Most often, the disease is localized to the anterior or posterior cervical chains (70-90%) or supra clavicular.

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