MRCP UK EXAMINATIONS

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ABDOMINAL

GENERALISED LYMPHADENOPATHY

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
A 45-year-old woman with a medical history of a menstrual cycle disturbance had curettage of the uterine cavity to obtain endometrial tissue for histopathologic analysis. Microscopic investigation revealed the increased quantity of the endometrial glands, their form irregularity. Some of glands were dilated or had a saw-like pattern. What is the most likely diagnosis?
A
Cystic glandular hyperplasia of endometrium
B
Placental polyp
C
Atypical hyperplasia of endometrium
D
Glandular polyp of endometrium
Explanation: 

Detailed explanation-1: -Endometrial carcinoma (EC) is the most common gynecologic malignancy in the developed world, and it has several histologic types. Endometrioid carcinoma (known as type 1 Type 1 Spinal Muscular Atrophy EC) typically develops from atypical endometrial hyperplasia.

Detailed explanation-2: -In an endometrial biopsy, a small piece of tissue from the lining of the uterus (the endometrium) is removed and examined under a microscope for cancer and other cell irregularities. The procedure helps find the cause of a woman’s heavy or irregular bleeding.

Detailed explanation-3: -Atrophic endometrial epithelium is low cuboidal to flattened, with a single row of dense nuclei. Mitotic activity is absent. There are four histological types of atrophic endometrium, atrophic inactive, atrophic/weakly proliferative (non-inactive), mixed (inactive and non-inactive), and cystic atrophic [1, 2].

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