MRCP UK EXAMINATIONS

ABDOMINAL

GENERALISED LYMPHADENOPATHY

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
A histological investigation of a thyroid gland biopsy, presented to pathology, revealed lymphoid structures with the germinal (growth) centers among the follicles filled with a colloid. What is the most likely disease presented in that case?
A
Hashimoto’s goiter.
B
Endemic goiter
C
Sporadic goiter
D
Basedow’s goiter
Explanation: 

Detailed explanation-1: -These thyroid follicles act as storage compartments filled with a substance called the colloid. This colloid is thyroglobulin, which is nothing but acidophilic secretory glycoprotein that is PAS-positive.

Detailed explanation-2: -A colloid cyst nodule is a common type of benign thyroid nodule that contains fluid. Nodules develop when thyroid tissue grows abnormally. With a colloid cyst nodule, the overgrowth can be extensive. Fortunately, colloid thyroid nodules don’t spread outside the thyroid.

Detailed explanation-3: -The diagnosis is often challenging and may take time until later in the disease process. The most common laboratory findings demonstrate an elevated thyroid-stimulating hormone (TSH) and low levels of free thyroxine (fT4), coupled with increased antithyroid peroxidase (TPO) antibodies.

There is 1 question to complete.