ABDOMINAL
GENERALISED LYMPHADENOPATHY
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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A histological investigation of the removed enlarged thyroid gland revealed irregular form and sizes follicles. The follicular epithelium proliferated both into follicles lumen and outside. Layers of the connective tissue separated various sites of the thyroid. What is the most likely diagnosis?
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Macro-microfollicular goiter
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Diffuse goiter
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Autoimmune thyroiditis
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Follicular carcinoma
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Explanation:
Detailed explanation-1: -Histologically, the thyroid gland is organized as epithelial cells surrounding colloid-containing pools, called follicles. The colloid is rich in thyroglobulin, a protein possessing many tyrosine residues to which iodine molecules attach to form the thyroid hormones.
Detailed explanation-2: -Histologically, the initial stage of colloid goitre is cellular hyperplasia of the thyroid acini, followed by a micronodular and macronodular formation, which is often indistinguishable from normal thyroid parenchyma, even on histological examination. True thyroid epithelial cysts are rare.
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