MRCP UK EXAMINATIONS

ABDOMINAL

GENERALISED LYMPHADENOPATHY

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
Which blood cells does human immunodeficiency virus have the most tropism to?
A
Erythrocytes
B
T-suppressor
C
T-killer
D
Platelets
E
T-helper
Explanation: 

Detailed explanation-1: -HIV can infect a variety of cells such as CD4+ helper T-cells and macrophages that express the CD4 molecule on their surface.

Detailed explanation-2: -Macrophage-tropic (M-tropic) viruses infect primary cultures of macrophages and CD4+ T cells and use CCR5 as the preferred coreceptor (2, 5, 15, 23, 26, 31). T-cell-tropic (T-tropic) viruses can infect primary cultures of CD4+ T cells and established T-cell lines, but not primary macrophages.

Detailed explanation-3: -HIV primarily targets a type of cell in the immune system called the CD4+ T cell. However, many types of these cells exist, and they are not all equally susceptible to infection by HIV.

There is 1 question to complete.