MRCP UK EXAMINATIONS

ABDOMINAL

THALASSEMIA

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
A
Promoter mutation
B
Gene deletion
C
Termination codon mutation
D
Splice site mutation
Explanation: 

Detailed explanation-1: -Alpha thalassemia is caused by mutations in two different genes, the HBA1 and the HBA2 genes. Most individuals inherit two copies of each gene (for a total of four genes); one of each from a person’s father, and one of each gene from a person’s mother.

Detailed explanation-2: --Thalassemia is common throughout Melanesia and is frequently caused by the known-3.7 and-4.2 mutations.

There is 1 question to complete.