couple come to consult about thalassemia disease The wife was 20 weeks pregnant and the results were as follows:Husband:Hb 13.5 g/dl, Hct 45%, MCV 80 fl, RDW 15% OF-ve, DCIP +ve Hb typing:HbA 68.7%, HbE 26%, HbF 0.6% $alpha$-. gene study:.....$alpha$3.7, $alpha$$alpha$Wife:Hb 10.5 g/dl, Hct 32 %, MCV 76.1 fl, RDW 17.1% OF +ve, DCIP +ve Hb typing:HbA 59.8%, HbE 32.1%, HbF 0.9% $alpha$-gene study:$alpha$$alpha$, $alpha$$alpha$ from the above results What is the chance of having a child without thalassemia? How many %?

THALASSEMIA

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Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]

couple come to consult about thalassemia disease The wife was 20 weeks pregnant and the results were as follows:Husband:Hb 13.5 g/dl, Hct 45%, MCV 80 fl, RDW 15% OF-ve, DCIP +ve Hb typing:HbA 68.7%, HbE 26%, HbF 0.6%

A	12.5
B	25
C	75
D	100

Explanation:

Detailed explanation-1: -The d-b thalassemia trait (db-TT) is characterized by ele-vation of Hb F, a normal or decreased level of Hb A2, and red cell indices similar to those of b-TT. Distribution of Hb F among red cells is heteroge-neous. A rise in RDW in db-TT would be expected because of the presence of two different red cell populations.

Detailed explanation-2: -Red cell distribution width values (RDW), one of the red blood cell indices, which will already have been reported in the complete blood count (CBC), reflects the degree of anisocytosis of red blood cells. This value has been used to differentiate between patients with IDA and a thalassemia trait for decades.

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MRCP UK EXAMINATIONS

ABDOMINAL

THALASSEMIA