ABDOMINAL
THALASSEMIA
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Hb H inclusions in a supravital stain preparation appear as:
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A few large, blue, round bodies in the RBCs with aggregated reticulum
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Uniformly stained blue cytoplasm in the RBC
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Small, evenly distributed, greenish-blue granules that pit the surface of RBCs
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Uniform round bodies that adhere to the RBC membrane
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Explanation:
Detailed explanation-1: -Supravital staining of red blood cells with brilliant cresyl blue (BCB) is used to detect hemoglobin H (Hb H). This simple test is useful in the diagnosis of alpha thalassemia trait; however, the search for Hb H containing cells in often very tedious.
Detailed explanation-2: -Haemoglobin H inclusions are only seen on supravital staining. They manifest as multiple purple inclusions, causing a ‘golf-ball’ appearance. Haemoglobin H inclusions are seen in haemoglobin H disease, which is a form of alpha thalassaemia.
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