MRCP UK EXAMINATIONS

ABDOMINAL

THALASSEMIA

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
Heterozygous
A
True
B
False
C
Either A or B
D
None of the above
Explanation: 

Detailed explanation-1: -Hb A2 is increased in beta thalassemia because the relative lack of beta globin allows more delta chains to be incorporated into hemoglobin. Beta thalassemia is caused by mutations in the beta globin gene locus on chromosome 11.

Detailed explanation-2: -Hemoglobin A2 levels in normal adults are rarely greater than 3.5%. In patients heterozygous for beta-thalassemia, they average about 5% but do not usually exceed 7%.

Detailed explanation-3: -Treatment may include: Regular blood transfusions. Medicines to reduce extra iron from your body (called iron chelation therapy) Surgery to remove the spleen, if needed.

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