MRCP UK EXAMINATIONS

ABDOMINAL

THALASSEMIA

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
Inherited disorders of globin synthesisGreatest prevalence in countries where ​ (a) function or synthesis
A
malaria
B
genetic alteration
C
globin chain
D
None of the above
Explanation: 

Detailed explanation-1: --thalassemias are caused by an -globin chain synthesis defect.

Detailed explanation-2: -Thalassemia can be defined as a condition in which a reduced rate of synthesis of one or more of the globin chains leads to imbalanced globin-chain synthesis, defective hemoglobin production, and damage to the red cells or their precursors from the effects of the globin subunits that are produced in relative excess.

Detailed explanation-3: -Approximately 70, 000 to 100, 000 Americans have sickle cell disease, the most common form of an inherited blood disorder. This disease, which is present in affected individuals at birth, causes the production of abnormal hemoglobin.

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