ABDOMINAL
THALASSEMIA
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Always weak and restless
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Jaundice
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There are no changes in the formation of the face as children grow
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Stunted growth
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Abdominal distension due to swelling of the liver and spleen
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Detailed explanation-1: -Changes in facial and cranial bones have been identified as the overexpansion of the bone marrow results in a typical facial appearance. The craniofacial features of thalassemia major patients include larger cheekbones, a rodent or “squirrel-like” face, a depressed nasal bridge, and a protruding maxilla.
Detailed explanation-2: -Children with beta thalassemia intermedia or major may not show any symptoms at birth, but usually develop anemia in the first 2 years of life. Signs of anemia in beta thalassemia intermedia or major may include: extreme tiredness. pale skin.
Detailed explanation-3: -Beta thalassemia major is caused by a homozygous mutation (beta-zero thalassemia) of the beta-globin gene, resulting in the total absence of beta chains. It manifests clinically as jaundice, growth retardation, hepatosplenomegaly, endocrine abnormalities, and severe anemia requiring life-long blood transfusions.