MRCP UK EXAMINATIONS

Detailed explanation-1: -The thalassemias (named from the Greek word for sea, thalassa1) are a group of inherited autosomal recessive hematologic disorders2 that cause hemolytic anemia because of the decreased or absent synthesis of a globin chain. Imbalances of globin chains cause hemolysis and impair erythropoiesis.

Detailed explanation-2: -Thalassemia is a heterogeneous group of autosomal recessive genetic disorders characterized by decreased or absent synthesis of globin chains, leading to anemia and microcytosis. Clinically, there are two major forms: ‐thalassemia and ‐thalassemia.

Detailed explanation-3: -Alpha and beta thalassemia are inherited hemoglobinopathies in which impaired production of one type of globin chain (alpha chains in alpha thalassemia; beta chains in beta thalassemia) causes an imbalance in the ratio between alpha and beta (or beta-like) chains, which is normally tightly controlled.