MRCP UK EXAMINATIONS

ABDOMINAL

THALASSEMIA

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
What is the name of the disorder when there is one Thalassemia gene and one Sickle gene?
A
Sickle Cell Thalassemia
B
Thalassemia Sickle
C
Sickle Cell Disease
D
Sickle Minor
Explanation: 

Detailed explanation-1: -People who have this form of SCD inherit a hemoglobin “S” gene from one parent and a gene for beta thalassemia, another type of hemoglobin abnormality, from the other parent. There are two types of beta thalassemia: “zero” (HbS beta0) and “plus” (HbS beta+).

Detailed explanation-2: -Thalassemia is a blood disorder passed down through families (inherited) in which the body makes an abnormal form or inadequate amount of hemoglobin. Hemoglobin is the protein in red blood cells that carries oxygen. The disorder results in large numbers of red blood cells being destroyed, which leads to anemia.

Detailed explanation-3: -Like Thalassemia, people with SCD are born with two sickle cell genes, one from each parent. Hemophilia is X-linked disorder, females carry gene and males are affected. About 30% cases are with new genetic mutations.

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