ABDOMINAL
THALASSEMIA
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Bone marrow transplant from parents
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Bone marrow transplant from friends
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Bone marrow transplant from siblings who also have thalassemia
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Bone marrow transplantation from healthy and HLA-matched siblings (matched sibling donor)
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Detailed explanation-1: -HCT relies on high-dose chemotherapy to eliminate thalassemia-producing cells in the marrow and replaces them with healthy donor cells from bone marrow or umbilical cord blood, usually taken from a human-leukocyte antigen (HLA) match: an identical sibling.
Detailed explanation-2: -Siblings have a 50% chance of being a half match, while parents are always a half match for their children, and vice versa. This gives a much better chance of finding a suitable donor.
Detailed explanation-3: -Siblings are most often selected as a donor since they have the greatest chance (25%) of being HLA-matched with the recipient [1].
Detailed explanation-4: -The only radical cure for homozygous thalassemia is to transplant bone marrow from an HLA-identical donor who is normal or heterozygous for thalassemia, which is capable of producing and maintaining a normal hemoglobin level in the recipient.