MRCP UK EXAMINATIONS

ABDOMINAL

THALASSEMIA

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
Which thalassemiapresents with an abnormal hgb that precipitates in red cells and will have a golf ball appearance after incubation with brilliant cresyl blue
A
Hgb F
B
Hgb H
C
Hgb Bart’s
D
Beta thal major
Explanation: 

Detailed explanation-1: -Heinz bodies are denatured haemoglobin (seen in oxidant injury, G6PD deficiency). Haemoglobin H inclusions are seen in alpha-thalassemias giving rise to the characteristic ‘golf ball’ appearance of the erythrocytes.

Detailed explanation-2: -In people with the characteristic features of alpha thalassemia, a reduction in the amount of hemoglobin prevents enough oxygen from reaching the body’s tissues. Affected individuals also have a shortage of red blood cells (anemia ), which can cause pale skin, weakness, fatigue, and more serious complications.

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