· Pamidronateo Bisphosphonate iv/bulano Metab. Bone, inflammation immune regulation Thalidomideo Entinflammatory-immunomodulating effect Relieve symptoms & acute phase reactants Sulfasalazineo 2-3 g/day 3-11 mth:↓ severe & long stiffness & pain Methotrexateo Minimal efficacy Is this statement true?

ANKYLOSING SPONDYLITIS

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Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]

A	Correct
B	Salah
C	Can be both
D	None of the above

Explanation:

Detailed explanation-1: -Bisphosphonates are primary agents in the current pharmacological arsenal against osteoclast-mediated bone loss due to osteoporosis, Paget disease of bone, malignancies metastatic to bone, multiple myeloma, and hypercalcemia of malignancy.

Detailed explanation-2: -Bisphosphonates are a group of drugs that can be used to help protect bones against the effects of some cancers and to treat some bone conditions. Sometimes bisphosphonates are called bone strengthening or bone hardening treatments. Bisphosphonates may be used to treat multiple myeloma and bone metastases.

Detailed explanation-3: -B-Mechanism of Action and Pharmacokinetics Pamidronate binds to hydroxyapatite and inhibits osteoclast migration and maturation. In cancer patients with bone metastases and multiple myeloma, lytic bone metastases are caused by increased osteoclast activity.

Detailed explanation-4: -Fever and flu-like symptoms. Low levels of calcium in your blood (hypocalcaemia) Bone and joint pain. Changes in bowel movements. Tiredness and low energy levels. Feeling sick. Changes to your kidneys. Irritation of the food pipe (oesophagus) More items •27-Nov-2019

There is 1 question to complete.

MRCP UK EXAMINATIONS

CLINICAL ENCOUNTERS

ANKYLOSING SPONDYLITIS