CLINICAL ENCOUNTERS
ANKYLOSING SPONDYLITIS
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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a. a. Recognition of HLA-B27 as an autoantigen
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a. Self-association of the HLA-B27 molecule
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a. Alteration of intracellular handling of microbes due to HLA-B27
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Arthritogenic peptides
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Detailed explanation-1: -Ankylosing spondylitis (AS) is a potentially disabling form of seronegative spondyloarthritis. The main symptom of AS is inflammatory spinal pain; with time, some patients develop ankylosis and spinal immobility. The pathology mainly affects the entheses, where ligaments, tendons and capsules are attached to the bone.
Detailed explanation-2: -The arthritogenic peptide hypothesis is one of the oldest hypotheses explaining the association between HLA-B*27 and SpA [27]. It proposes that some HLA-B*27 subtype alleles, due to their characteristic amino acid residues, bind a specific arthritogenic peptide that is recognized by CD8+ T cells [28].
Detailed explanation-3: -Ankylosing spondylitis, also known as axial spondyloarthritis, is an inflammatory disease that, over time, can cause some of the bones in the spine, called vertebrae, to fuse. This fusing makes the spine less flexible and can result in a hunched posture. If ribs are affected, it can be difficult to breathe deeply.
Detailed explanation-4: -As an autoimmune disease, AS develops through complex interactions between genetic background and environmental factors.