CLINICAL ENCOUNTERS
ANKYLOSING SPONDYLITIS
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Arthritogenic peptides
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Self-association of the HLA-B27 molecule
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Alteration of intracellular handling of microbes due to HLA-B27
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None of the above
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Detailed explanation-1: -Acute anterior uveitis (AAU) has been strongly linked with HLA-B27 and is the most common cause of non-infectious uveitis.
Detailed explanation-2: -A positive test means HLA-B27 is present. It suggests a greater-than-average risk for developing or having certain autoimmune disorders. An autoimmune disorder is a condition that occurs when the immune system mistakenly attacks and destroys healthy body tissue.
Detailed explanation-3: -HLA-B27 binds and presents peptides from influenza, HIV, Epstein-Barr virus, and other viruses. This leads to vigorous and specific cytotoxic T lymphocyte responses, which play an important role in the body’s immune response to these viruses. HLA-B27 thus carries out its natural function highly effectively.
Detailed explanation-4: -Anterior uveitis (AU) is present in up to 90% of cases of uveitis and approximately 50% of all patients with acute AU (AAU) are human leukocyte antigen B27 (HLA B27) positive. HLA B27 is also strongly associated with ankylosing spondylitis (AS), reactive arthritis (ReA), and other spondyloarthropathies (SpA) (6).