MRCP UK EXAMINATIONS

CLINICAL ENCOUNTERS

ANKYLOSING SPONDYLITIS

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
True or False:Ankylosing Spondylitis falls under the pathophysiological umbrella of Spondyloarthritis
A
True
B
False
C
Either A or B
D
None of the above
Explanation: 

Detailed explanation-1: -Spondyloarthritis is a group of diseases characterized by inflammation in the spine (“spondylitis”) and joints (“arthritis”). Types of spondyloarthritis include: Ankylosing spondylitis. Axial spondyloarthritis.

Detailed explanation-2: -Ankylosing spondylitis (AS), a common type of spondyloarthropathy, is a chronic inflammatory autoimmune disease that mainly affects spine joints, causing severe, chronic pain; additionally, in more advanced cases, it can cause spine fusion.

Detailed explanation-3: -Spondyloarthritis (SpA) is characterized by inflammation and new bone formation in the spine and entheses. The disease is the result of a complex interplay among susceptibility genes, microbial triggers, inflammation of bone marrow, and the enthesial structures and new bone formation.

Detailed explanation-4: -Ankylosing spondylitis, also known as axial spondyloarthritis, is an inflammatory disease that, over time, can cause some of the bones in the spine, called vertebrae, to fuse. This fusing makes the spine less flexible and can result in a hunched posture. If ribs are affected, it can be difficult to breathe deeply.

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