MRCP UK EXAMINATIONS

Detailed explanation-1: -Secondary hemostasis refers to the cascade of enzymatic reactions that ultimately results in the conversion of fibrinogen to fibrin monomers. Fibrin monomers are then cross-linked into insoluble strands that serve to stabilize the loose platelet clot formed in primary hemostasis.

Detailed explanation-2: -In addition to their role in primary hemostasis, activated platelets provide an efficient catalytic surface for the assembly of the enzyme complexes of the blood coagulation system, also known as secondary hemostasis.

Detailed explanation-3: -Good secondary hemostasis is dependent on appropriate and adequate clotting actor interactions leading to formation of the fibrin clot. Hemophilia A and B, Heparin, Coumadin, and cirrhosis of the liver are some causes for clotting factor deficiency.

Detailed explanation-4: -Coagulation cascade: a sequence of events triggered by the activation of the intrinsic or extrinsic pathway of coagulation that results in the formation of a stable thrombus. Coagulation factors. Substances that interact with each other to promote blood coagulation. 15-Jul-2022