MRCP UK EXAMINATIONS

Detailed explanation-1: -NICE and the BNF suggest that contraindications to all heparins include trauma, epidural half-life, hemorrhagic disorders, peptic ulcer disease, recent cerebral hemorrhage, severe hypertension, and recent surgery to the eye or nervous system.

Detailed explanation-2: -Low molecular weight heparin is used to prevent blood clots and to treat venous thromboembolism (deep vein thrombosis and pulmonary embolism). Low molecular weight heparin is also used in the treatment of myocardial infarction.

Detailed explanation-3: -LMWH is administered via subcutaneous route. This can be achieved by either by rotating injection sites or by injecting into an insuflonTM catheter. Direct subcutaneous injection should be given into a subcutaneous tissue skinfold of the abdomen or the upper-outer aspect of the thigh.

Detailed explanation-4: -LMWH should be used with care in patients with impaired renal function because it may bioaccumulate. Evidence exists that such bioaccumulation may cause bleeding, particularly with enoxaparin, which has the largest published experience in this setting.