MRCP UK EXAMINATIONS

Detailed explanation-1: -Low-molecular-weight heparins are primarily administered by the subcutaneous (SC) route and are generally considered ineffective when given orally. Our laboratory, however, has provided evidence that LMWHs are absorbed following oral administration.

Detailed explanation-2: -Although LMWH and UFH work similarly to inhibit clotting factors, LMWH can be self-administered at home via subcutaneous (under the skin) injection and does not require regular blood monitoring necessary for UFH treatment. As with all heparins, LMWH dosing is based on a patient’s weight.

Detailed explanation-3: -Heparin is not orally absorbed, presumably because of its size and polyanionic charge and hence is administered parenterally, either by continuous or intermittent infusion or by subcutaneous (SC) injection.

Detailed explanation-4: -Heparin is not absorbed in the gastrointestinal tract, presumably because of its size and ionic repulsion from negatively charged epithelial tissue. As such, it has poor oral bioavailability and is administered parenterally, either by continuous or intermittent infusion or by deep subcutaneous injection.