CLINICAL ENCOUNTERS
ANTICOAGULATION
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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product of vasoconstriction
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product of degradation
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product of fibrinolysis
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product of primary and secondary hemostasis
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Detailed explanation-1: -D-Dimer is a fibrin degradation product. It is named as such because it contains two cross-linked D fragments of the fibrin protein. Increased levels imply increased fibrinolysis and can be seen in DIC and thrombotic states.
Detailed explanation-2: -D-dimer is the degradation product of crosslinked (by factor XIII) fibrin. It reflects ongoing activation of the hemostatic system.
Detailed explanation-3: -Levels of D-dimer and fibrinogen/fibrin degradation products (FDPs) are significantly elevated in patients with deep venous thrombosis, pulmonary embolism, disseminated intravascular coagulation, or other complications. The diagnosis of these disorders can be difficult, time-consuming, and expensive.
Detailed explanation-4: -Definition. Fibrin degradation products (FDPs) are the substances left behind when clots dissolve in the blood. A blood test can be done to measure these products.
Detailed explanation-5: -The D-dimer antigen is a unique marker of fibrin degradation that is formed by the sequential action of 3 enzymes: thrombin, factor XIIIa, and plasmin.