MRCP UK EXAMINATIONS

CLINICAL ENCOUNTERS

ANTICOAGULATION

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
What is D-Dimer?
A
product of vasoconstriction
B
product of degradation
C
product of fibrinolysis
D
product of primary and secondary hemostasis
Explanation: 

Detailed explanation-1: -D-Dimer is a fibrin degradation product. It is named as such because it contains two cross-linked D fragments of the fibrin protein. Increased levels imply increased fibrinolysis and can be seen in DIC and thrombotic states.

Detailed explanation-2: -D-dimer is the degradation product of crosslinked (by factor XIII) fibrin. It reflects ongoing activation of the hemostatic system.

Detailed explanation-3: -Levels of D-dimer and fibrinogen/fibrin degradation products (FDPs) are significantly elevated in patients with deep venous thrombosis, pulmonary embolism, disseminated intravascular coagulation, or other complications. The diagnosis of these disorders can be difficult, time-consuming, and expensive.

Detailed explanation-4: -Definition. Fibrin degradation products (FDPs) are the substances left behind when clots dissolve in the blood. A blood test can be done to measure these products.

Detailed explanation-5: -The D-dimer antigen is a unique marker of fibrin degradation that is formed by the sequential action of 3 enzymes: thrombin, factor XIIIa, and plasmin.

There is 1 question to complete.