MRCP UK EXAMINATIONS

Detailed explanation-1: -Citrate chelates calcium making it biologically unavailable. This inhibits the propagation of the coagulation cascade. Calcium citrate complexes are removed at a rate of 20–50% across the hemofilter. The remaining free citrate posthemofilter is available to chelate any remaining calcium.

Detailed explanation-2: -Intracellular calcium chelator BAPTA protects cells against toxic calcium overload but also alters physiological calcium responses. Cell Calcium.

Detailed explanation-3: -The chelating agent calcium ethylenediaminetetraacetic acid (EDTA) (calcium disodium salt of EDTA) is indicated for acute exposure if administered shortly after cadmium exposure before new metallothionein is synthesized.

Detailed explanation-4: -Citrate, which chelates positively charged calcium ions and thereby blocks calcium-dependent clotting factor reactions, is the anticoagulant typically used for collection of blood for transfusion as well as for in vitro evaluation of platelet function.