CLINICAL ENCOUNTERS
ANTICOAGULATION
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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It will remove Ca2+ through chelation.
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It will forms a complex with antithrombin III, catalyzing the inhibition of thrombin.
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It will removes calcium from coagulation system by precipitating it into unusable form.
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It will add calcium ion in blood preventing clotting.
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Detailed explanation-1: -Mechanism of Action EDTA is rapidly absorbed through intravenous access and moves into the plasma and interstitial fluids. Oral administration is avoided due to very low (less than 5%) absorption and elevated lead concentrations within the gastrointestinal tract.
Detailed explanation-2: -Mechanism of Action Calcium EDTA is a chelating agent with an affinity for divalent and trivalent metals. Once administered, the calcium component of calcium EDTA can be displaced by other divalent and trivalent metals, forming stable, soluble complexes that are then excreted by the kidneys.
Detailed explanation-3: -Disodium EDTA is a chelating agent used in studies involving calcium. The sodium ion of the chelate is displaced by calcium to form soluble, non-toxic physiologically unavailable complexes that are excreted through urine.
Detailed explanation-4: -Of the man-made ones it is the aminocarboxylic acids that predominate. In a solution of EDTA (ethylenediaminetetracetate) ion, a common synthetic chelating agent, six co-ordinate bonds are formed to a calcium ion.