MRCP UK EXAMINATIONS

Detailed explanation-1: -Bone resorption begins increasing 2 years before the final menstrual period (FMP), peaks approximately 1.5 years after the FMP, and then plateaus. In concert with increases in bone resorption, there is a rapid phase of bone loss during the menopause transition, in a 3-year period around the FMP.

Detailed explanation-2: -Women lose about 50% of their trabecular bone and 30% of their cortical bone during the course of their lifetime, about half of which is lost during the first 10 yr after the menopause (1, 2). Approximately 40% of all postmenopausal women will eventually experience fractures (1, 2).

Detailed explanation-3: -At stage 1 of osteoporosis, a person’s bone loss and bone formation develop at the same rate. This means they no longer make more bone material than they are losing. A doctor may consider this stage 1 of osteoporosis because the formation of new bone does not outpace a person’s bone loss.