MRCP UK EXAMINATIONS

Detailed explanation-1: -Another common osteoporosis medication is denosumab (Prolia, Xgeva). Unrelated to bisphosphonates, denosumab might be used in people who can’t take a bisphosphonate, such as some people with reduced kidney function. Denosumab is delivered by shallow injections, just under the skin, every six months.

Detailed explanation-2: -Alendronate (Fosamax), risedronate (Actonel) and ibandronate (Boniva) are available orally. The former two agents can be taken daily or weekly; the latter two agents can be taken daily or monthly. Pamidronate (Aredia), ibandronate (Boniva) and zoledronic acid (Reclast) are available intravenously.

Detailed explanation-3: -Based on the meta-analysis, denosumab is superior in improving lumbar spine BMD compared with bisphosphonates. However, there were no significant differences in total hip and femoral neck BMD improvement between two groups. It is clear denosumab is effective at improving BMD in trabecular bone [29].