CLINICAL ENCOUNTERS
PSORIASIS
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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dendritic cells
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T lymphocytes
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Neutrofilos
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All of the above are cells involved in the physiopathogenesis of psoriasis.
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Only T lymphocytes are involved
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Detailed explanation-1: -Psoriasis involves hyperproliferation of the keratinocytes in the epidermis, with an increase in the epidermal cell turnover rate. (See Pathophysiology.) The cause of the loss of control of keratinocyte turnover is unknown. However, environmental, genetic, and immunologic factors appear to play a role.
Detailed explanation-2: -Psoriasis is one of the most common immune-mediated chronic, inflammatory skin diseases characterized by hyperproliferative keratinocytes and infiltration of T cells, dendritic cells, macrophages and neutrophils.
Detailed explanation-3: -In psoriasis there is an intense crosstalk between innate immune cells (e.g. dendritic cells (DCs), macrophages, neutrophils), adaptive immune cells (B and T cells) and resident skin cells (e.g. keratinocytes, melanocytes, and endothelial cells). These interactions appear to amplify and sustain chronic inflammation.